ADEQUATE REST

HEALTHY BREAK

SERENIL

Valerian, linden, passionflower & vitamin B1

A mixture of herbs is obtained from the combination of valerian, linden and passionflower that acts on the central nervous and vegetative systems in particular.
Valerian is one of the most important herbs used for this purpose. Among the main components obtained from its roots, we can find valepotriates and valerenic acids. On the other hand, linden and passionflower provide flavonoids, among which chrysin and kaempferol stand out, which would be the substances responsible for their properties.
The presence of vitamin B1 is due to the fact that its insufficiency can cause symptoms of nervous irritability.

Properties
There is abundant scientific evidence that associates the use of valerian, passionflower and linden to circumstances that lead people to a state of imbalance in the most diverse activities, such as: 
1) A hectic daily life that does not allow you to sleep well.
2) Conduct disorders with manifestations of anguish, inner tension and irritability.
3) Before exams and crises at work.
4) Nervousness and restlessness caused by the environment where people live in.
 
Formula
Contribution to intake 2 comprimidos
Nutrient%IDR
Extracto seco de valeriana officinalis
200 mg
--

Extracto seco de tilo
150 mg
--

Extracto seco de pasionaria
150 mg
--

Vitamina B1 (Tiamina)
4 mg
333

CONTAINS MILK DERIVATIVES
Nutritional Information

Serving: 2 tablets. This product does not provide significant amounts of energy value, carbohydrates, proteins, total fat, saturated fat, trans fat, dietary fiber or sodium.

Presentation

50 tablets

Recommended intake

To start with, take 2 tablets a day for 4 or 5 days, preferably 1 tablet after breakfast and 1 tablet one hour before bedtime. In the following days, take 1 tablet one hour before going to bed. The suggested dose exceeds the Recommended Daily Intake (RDI) of vitamin B1. 
 

Contraindications

Not to be taken by pregnant or lactating women, or by children. Not to be taken by people with intolerance to the ingredients of the formula, or by people who must drive vehicles, operate machinery or equipment that require special attention. Alcohol can enhance the product’s sedative effect.

Biographic reference
› Bent, S. y otros. Valeriana para dormir: una revisión y análisis estadístico sistemático. (2006). American Journal of Medicine. 119: 1005-1012. Disponible en: https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC4394901/pdf/nihms455706.pdf
› Fernández San Martín M.I., Masa Font R., Palacios Soler L. y otros. Efectividad de la valeriana para el insomnio: un análisis estadístico de ensayos aleatorios controlados versus placebo. (2010).  Sleep Med.; 11(6):505-11. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/20347389
› Ziegler G., Ploch M., Miettinen-Baumann A. Eficacia y tolerabilidad del extracto de valeriana LI156 en comparación con oxazepam en el tratamiento del insomnio no orgánico: un estudio clínico aleatorizado, doble ciego, comparativo. (2002). Eur. Journal Med. Res.; 7:480–6. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/12568976
› Houghton P.J. La base científica de la renombrada actividad de la valeriana. (1999).  Journal Pharm. Pharmacol.; 51(5):505-12. Disponible en: https://onlinelibrary.wiley.com/doi/abs/10.1211/ 0022357991772772
› Diaper A., Hindmarch I. Una investigación doble ciego controlada por placebo de los efectos de dos dosis de una preparación de valeriana en el sueño, la función cognitiva y psicomotora de adultos mayores con trastornos del sueño. (2004). Phytother. Res.;18(10):831-6. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/15551388
› Kamaldeep Dhawan, Suresh Kumar, Anupam Sharma. Estudios anti-ansiedad en extractos de Passiflora incarnata Linneaus. (2001). Journal of Ethnopharmacology. 78 (2–3): 165-170. Disponible en: https://doi.org/10.1016/S0378-8741(01)00339-7
› Gazola A.C., Costa G.M., Zucolotto S.M., Castellanos L., Ramos F.A. Monteiro de Lima T.C., Lima Schenkel E.P. La actividad sedante de los flavonoides de Passiflora quadrangularis está mediada a través de la vía GABAergic. (2018). Biomedicine & Pharmacotherapy. 100:388-393. Disponible en: https://doi.org/10.1016/j.biopha.2018.02.002
› Guerrero F.A., Medina G.M. Efecto de una planta medicinal (Passiflora incarnata L) sobre el sueño. (2017). Sleep Sci.; 10(3): 96–100. Disponible en: https://www.ncbi.nlm.nih.gov/pmc /articles/PMC5699852/pdf/ssci-10-03-0096.pdf
› Kamaldeep Dhawan, Suresh Kumar y Anupam Sharma.  Evaluación de los efectos del sistema nervioso central de Passiflora incarnata en animales experimentales. (2003). Pharmaceutical Biology, 41(2):87-91. Disponible en: https://www.tandfonline.com/doi/pdf/10.1076/phbi.41.2.87.1424
› Elsasa S.M., Rossi D.J. y otros. Extracto de Passiflora incarnata L. (Passionflower) provoca corrientes de GABA en neuronas del hipocampo in vitro, y muestra efectos ansiogénicos y anticonvulsivos in vivo, que varían según el método de extracción. (2010). Phytomedicine.; 17(12): 940–949. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941540/pdf/nihms187812.pdf
› Herrera Ruiz M., Román R., Ramos A.Z., Tortoriello J., Jiménez- Ferrera E.  Flavonoides de Tilia americana con actividad ansiolítica prueba del laberinto positivo. (2008). Journal of Ethnopharmacology. 118 (2): 312-317. Disponible en: https://www.sciencedirect.com/science/article/pii/S0378 874108002237
› Aguirre-Hernández E, González-Trujano M.E., Martínez A.L., Moreno J., Kite G., Terrazas T., Soto-Hernández M. Análisis de HPLC / MS y efecto ansiolítico de los flavonoides de quercetina y kaempferol de Tilia americana var. Mexicana. (2010). Journal of Ethnopharmacology. 127 (1): 91-97. Disponible en: https://www.sciencedirect.com/science/article/pii/S0 378874109006047
› Cotrim M.D., Figueiredo I.V. y otros. Propiedades farmacológicas del extracto acuoso de tilia europeae: screening de la actividad ansiolítica / sedante en ratones. (1999). Arq. Parol, XXXI: 23-29. Disponible en: https://pdfs.semanticscholar.org/5684/0e08d2cf64
 

Active compounds

PASSION FLOWER

Passion flower is a type of bushy vine whose main action is related to its anxiolytic effect. Studies show its effect in helping to calm nerves and stress. 

VALERIAN

Valerian is a well-known plant used for the treatment of nervous disorders. There is evidence associating the use of valerian for circumstances that lead people to a state of imbalance in the most diverse activities, such as a hectic daily life with experiences that do not allow people to fall asleep, behavioral disorders with manifestations of anguish, and inner tension and irritability prior to exams and work crises. 

LINDEN

Linden is a deciduous tree. Scientific studies associate linden to sedative and antispasmodic activity

ADEQUATE REST

WHAT IS YOUR SLEEP SITUATION?

Insomnia

Many people experience temporary insomnia in their lives, but when insomnia becomes chronic it requires medical attention. There are healthy habits before going to sleep that can improve this situation, such as not watching TV or social networks in bed, not consuming caffeine or stimulants, nor alcohol and cigarettes before going to sleep.

I sleep too little

The amount of sleep varies from person to person and age to age. An adult should sleep between 7 and 8 hours a day. Sleeping fewer hours can contribute to an increased risk of hypertension and cardiovascular disease, among others.

Interrupted sleep

Sleep interruptions are often detrimental to our health. Proper sleep is necessary to be healthy. Early medical consultation and good pre-sleep habits will help you.

I sleep too much

Oversleeping can cause light, inconsistent and unrefreshing sleep, which is not what our body needs. Prolonged sleep can affect concentration and proper brain activity in your daily routine.

Daily sleepiness

Excessive daytime sleepiness can be a sign of a sleep disorder. Anxiety, stress and boredom may contribute to this feeling, which should be a reason for a medical consultation.

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